Introduction

GC-LC CONCORDANCE software by SPECTROCHROM automates chromatograms comparisons between complex products (up to 1000 compounds in a mixture), by simultaneously correcting retention time shifts and random fluctuations of retention times (RT) or retention index (RI) (Kovats) of these components due to column degradation (due to the ageing of the columns, injection mode, gas control, etc.)

Unique Software for the Automatic Chromatograms Comparison of Complex Chromatograms

GC-LC CONCORDANCE is a unique software, mixing theories of the deductive mathematics of polynomials functions (P=AnX^n with n=30) and algorithms of the neurological networks (recognition and adaptability).

Chromatograms in HPLC of protein extracts of the cellular proteomics.

Typical applications are control of raw materials and finished products in the perfume industry, but also to oils, petrol residues, proteomic and pollution. More generally, it concerns chemistry products controlled by GC and HPLC chromatography techniques.

Indeed, phase ageing of the column varies in non-linear and random ways depending on injected products and their concentrations.

The reasons of these variations in GC or LC:

• Injection mode
• Gas control
• Temperature control
• Chemistry of the Injected product
• Reconditioning of the Gas chromatograph
• Sample impurities
• Phase oxidation (O2 in carrier gas)
• Quality of pumps in HPLC

Upon repeating analysis, retention time differences of components will vary from seconds to minutes. Moreover, if the analyzed product has hundreds of components separated by a few seconds on the chromatogram, the manual identification is long, difficult and is subject to human error.

Today even if a gas chromatograph has all the new electronic regulation developments of temperature and gas flow rates, it is unable to balance these complex variations.

An automatic and accurate analysis is now possible with GC-LC CONCORDANCE!